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🐾 Elevate your dog’s liver health and mental sharpness—because every tail deserves to wag with vitality!
This Liver Health Supplement for Large Dogs combines 425mg of S-Adenosylmethionine (SAMe) and 35mg of Silybin from Milk Thistle in a pure, vet-designed formula. It supports liver detoxification, reduces inflammation, and enhances cognitive function, all in an easy-to-administer, gluten-free, non-GMO tablet. Trusted by pet owners and experts alike, it offers premium liver care at an accessible price point.






| ASIN | B09YMTS54V |
| ASIN | B09YMTS54V |
| Active Ingredients | S-adenosylmethionine (SAMe) 425 mg, Silybin A+B 35 mg (from 120 mg of Milk Thistle) |
| Allergen Information | Crustacean Free, Egg Free, Gluten Free, Non-GMO, Nut Free |
| Best Sellers Rank | #4,471 in Pet Supplies ( See Top 100 in Pet Supplies ) #21 in Dog Herbal Supplements |
| Brand Name | SilymarinAdvanced |
| Customer Reviews | 4.4 4.4 out of 5 stars (431) |
| Date First Available | May 15, 2022 |
| Dog Breed Size | Large |
| Flavor | Other |
| Global Trade Identification Number | 00195893767946 |
| Included Components | S-Adenosylmethionine, SAMe, Silybin A+B, Milk Thistle, Silymarin |
| Item Form | Tablet |
| Item Type Name | Liver Tablets |
| Item model number | SA004 |
| Manufacturer | Vet Perfect Inc |
| Manufacturer | Vet Perfect Inc |
| Product Benefits | Heals liver illness and inflammation. Eliminates toxins and harmful chemicals. Enhances cognitive brain functions. |
| Product Dimensions | 1.9 x 1.9 x 3.5 inches; 2.08 ounces |
| Target Species | Dog |
| Unit Count | 30.0 Count |
| Warranty Description | 2 Year Manufacturer |
R**L
Fair cost, great results
We were giving our senior pitbull a lover supplement that is brand name and cost about $76 and it just wasn't sustainable for our family to continue to have to pay that. So I did the research. This actually has the same ingredients but at a much more reasonable price and it's easier for her to absorb! Perhaps it's the form the tablet comes in but either way she takes it no problem and there isn't a battle each time. Actually she gets excited for her medicine time because of it!
P**.
Better for your dog
My dog does so much better on this medicine than on densmarin
D**A
Helping
Like many of you' I'd do anything to help my Raider a 13 you lab mix live a longer healthier happy life. This supplement is part of his regime. Since taking while his numbers have gone up slightly they have only gone up slightly, an improvement from before taking. I break them in two and put two tablets in his food. I wish they would come in a larger size container as this last only 15 days. Good supplement.
G**P
Taste
My senior dog takes many pills. I thought one less would be great. I’ve cooked for her for 5 years for her liver disease. Takes dasaquin prior to trying this. But, after grinding it to put in her morning food, she really isn’t excited about the taste which she eats every morning with gusto. She won’t finish it all so that means not a full dosage. I guess I will have to give as a pill and then go back to dasaquin. Seems like the price is great and it can be given anytime which is wonderful especially if they take multiple pills that need spaced. Just didn’t work for my 16 year old. I think chewing would be difficult. She has all her teeth but when I use the mortar to crush it takes some work, which I know she wouldn’t like.
B**.
Vet says it's just as good as the name brand that starts with D but way cheaper.
My dogs been on these daily for a couple of years now since he became diabetic per vet's advice and he's been doing great on every check up. Way cheaper than the name brand that starts with a D that the vet's like to push but my vet is very understanding she said this is just as good and way cheaper.
M**Z
Works for my dog!
My senior dog has been using this supplement for over a year now. A few months before she started taking this, she used to take Denamarin. She had elevated liver enzymes. I think it was 50-75 over the highest normal. Denamarin did it’s job. However, it wasn’t cost-effective for me, so I looked for an alternative. I found this. I read the reviews first, and I took a chance. Fast forward 6 months after she started taking this, my dog’s liver enzymes was only 5 above the highest normal. Another 6 months passed, which was the week of Thanksgiving 2025, her liver enzymes were only 1 above the highest normal. As far as side effects, she had none. I give it to her with her first meal of the day. This supplement is doing it’s job for my dog.
D**.
Highly recommend this
Works great and really helped my senior dog bring their liver numbers down. Just wish they would offer promos more
X**O
AVOID- MAJOR SIDE EFFECTS!
I purchased this supplement for the same reason we all did— a cheaper alternative. Well, this was NOT an alternative at all. In fact, it’s caused major side effects in my dog. She was on this product for almost a full month. Through the month I noticed her behavior change significantly & became extremely worried. Extremely lethargy + sleeping almost 24/7 towards the final week she was on it. Restlessness at night. No energy for walks, she seemed like a shell of her normal self- very distant. Soft stool, loss of appetite & difficulty walking after the 3rd week. I was trying to pinpoint how she could have so many issues occur so quickly. I realized they all began after starting these pills. I skipped her dose for ONE day, and BAM— she’s significantly improved by the next day. Perky, playful, sassy, AWAKE, less issues walking, she seems more comfortable.. and I suspect she will continue to go back to her normal self as I throw the remaining pills in the TRASH. BE CAREFUL. I wouldn’t recommend this to anyone because it put my dog at more risk, & caused significant issues. Side effects are MAJOR.
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