TMG, trimethylglycine, Encourages Healthy homocysteine Levels, Non-GMO, Gluten-Free, Vegetarian, 60 Capsules

This Life Extension TMG is a solid, no‑nonsense supplement. The capsules are easy to take, the formula is clean, and it fits well into a daily routine. A reliable option if you want straightforward support without any unnecessary additives.

The primary reason for adding TMG when using NMN or NR is because they increase intracellular NAD⁺ levels which accelerates the activity of methyltransferase enzymes. This can create a significant demand for methyl groups and temporarily elevate homocysteine if methyl donors are insufficient. TMG serves as a methyl donor directly converting homocysteine back to methionine via the betaine-homocysteine methyltransferase pathway. Two capsules with breakfast provide exactly the 1–1.5 g range frequently cited in longevity-focused protocols. For anyone incorporating NMN, NR, or high-dose niacin into a longevity regimen, I consider TMG essential for maintaining methylation balance and minimizing potential homocysteine elevation. This particular TMG offering from Life Extension delivers reliable purity, potency, and value.

This has been a great addition alongside my methylated B vitamins. I take the TMG at night since it makes me a bit sleepy, and it feels like a supportive combo for overall restoration and balance. Clean formula and easy to incorporate into my routine.

The difference is amazing! I started taking this to help with better absorption of my vitamins. I notice a huge difference and I feel better since taking it. I feel my health is much better since taking this. I feel like I can finally feel the benefits of my B complex vitamins. I take two in the morning with my b complex vitamins (Thorne MethlGaurdPlus) on an empty stomach with no problem. No upset to my stomach. I’ve been taking for a few months now without any issues. Great price and quality. Easy enough to swallow. A must have if you have Issues with methylation that are common with gene mutation.

TMG by Life Extension is the best. I tried the powdered capsule from another brand and hated it. Something about the liquid capsule form and the quality of the product makes me feel better throughout the day. I would highly recommend you give this one a try!

I bought this product about 6 times and the most recent bottles have had leaky capsules. The liquid gets all over the other pills, so I can't put them in my pill boxes. I am going to look for a replacement even though I really like this one.

Appears to be good clean quality and transparent capsules where you can see the product. I took a methylation test a while back and discovered partial COMT varient issues. In taking these I notice a sustained energy throughout the day. Not sure if it's just a coincidence at this point but I will be continuing with this brand's tmg.

TMG can be tough on the digestion in powder, tablets or powder capsules. This form is the best. It does not have any unhealthy additives and can be taken as one capsule twice daily or two at one time. I have tried other form and was glad I had tried this. I think the LE capsules are the perfect solution for people that find TriMethylGlycine or betaine harsh to digest. Without products like this one that are created by thinking "outside the box", many might avoid taking TMG. Yet TMG is so great for many, It supports methylation, liver health and SAMe production in the body. Would definitely recommend!!

Effective! My 4th or 5th bottle!

Las pildoras vienen mojadas y llenas de granitos. Parace que algunas de ellas explotaron y embarraron a las demás. No lo vuelvo a comprar

Great! Using to lower my Homocysteine levels!

The pill size is so large, that it is not comfortable to swallow (with water ofc).

Me encanta, buena relación precio/ calidad