---
product_id: 146465029
title: "Vanguard Plus 5/4L, Green, Box 25"
brand: "pfizer animal health"
price: "$U13928"
currency: UYU
in_stock: true
category: "product"
url: https://www.desertcart.uy/products/146465029-vanguard-plus-5-4l-green-box-25
store_origin: UY
region: Uruguay
---

# Vanguard Plus 5/4L, Green, Box 25

**Brand:** pfizer animal health
**Price:** $U13928
**Availability:** ✅ In Stock

## Quick Answers

- **What is this?** Vanguard Plus 5/4L, Green, Box 25 by pfizer animal health
- **How much does it cost?** $U13928 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.uy](https://www.desertcart.uy/products/146465029-vanguard-plus-5-4l-green-box-25)

## Best For

- pfizer animal health enthusiasts

## Why This Product

- Trusted pfizer animal health brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Description

Description                                                    This is an over the counter product - it does not require prescription.Ships on ICE, Please choose 2nd day Shipping for this item.  For Canada customers, please choose Worldwide Saver as the shipping method. The vaccine component of VANGUARD&#194;&#174; Plus 5/L contains attenuated strains of  CD virus, CAV-2, CPI virus, and CPV propagated on an established canine cell line.  The CPV fraction is high titer (107.0 TCID50/dose) and was attenuated by low passage  (35 passes from the canine isolate with a maximum of 2 additional passes allowed  for production) on the canine cell line which gives it the immunogenic properties  capable of overriding maternal antibody interference at the levels indicated in  Table 2. Some puppies in the field may have higher levels of maternal antibodies  than those evaluated in our pivotal efficacy study. The vaccine is packaged in  freeze-dried form with inert gas in place of vacuum. The bacterin component, containing  inactivated whole cultures of L. canicola and L. icterohaemorrhagiae, is supplied  as diluent.  Contains penicillin and streptomycin as preservatives.  Indications: VANGUARD&#194;&#174; Plus 5/L is for vaccination of healthy dogs    6 weeks of age or older as an aid in preventing canine distemper caused by canine    distemper (CD) virus, infectious canine hepatitis (ICH) caused by canine adenovirus    type 1 (CAV-1), respiratory disease caused by canine adenovirus type 2 (CAV-2),    canine parainfluenza caused by canine parainfluenza (CPI) virus, canine parvoviral    enteritis caused by canine parvovirus (CPV), and leptospirosis caused by Leptospira    canicola and L. icterohaemorrhagiae.  Directions:   1. General Directions: Vaccination of healthy dogs is recommended. Aseptically    rehydrate the freeze-dried vaccine (VANGUARD&#194;&#174; Plus 5) with the liquid bacterin    provided (Leptoferm C-I&#194;&#174;), shake well, and administer 1 mL subcutaneously    or intramuscularly.    2. Primary Vaccination: Healthy dogs 6 weeks of age or older should receive    3 doses, each administered 3 weeks apart.    3. Revaccination: Annual revaccination with a single dose is recommended.  Precaution(s): Store at 2&#194;&#176;-7&#194;&#176;C. Prolonged exposure to higher    temperatures and/or direct sunlight may adversely affect potency. Do not freeze.   Use entire contents when first opened.  Sterilized syringes and needles should be used to administer this vaccine.    Do not sterilize with chemicals because traces of disinfectant may inactivate    the vaccine.  Burn containers and all unused contents.  Caution(s): Vaccination of pregnant bitches should be avoided.  As with many vaccines, anaphylaxis may occur after use. Initial antidote of    epinephrine is recommended and should be followed with appropriate supportive    therapy.  This product has been shown to be efficacious in healthy animals. A protective    immune response may not be elicited if animals are incubating an infectious    disease, are malnourished or parasitized, are stressed due to shipment or environmental    conditions, are otherwise immunocompromised, or the vaccine is not administered    in accordance with label directions.  For use in dogs only.  Warning(s): For veterinary use only.  Disease Description: CD is a universal, high-mortality viral disease with variable    manifestations. Approximately 50% of nonvaccinated, nonimmune dogs infected    with CD virus develop clinical signs, and approximately 90% of those dogs die.1    ICH, caused by CAV-1, is a universal, sometimes fatal, viral disease of dogs    characterized by hepatic and generalized endothelial lesions. CAV-2 causes respiratory    disease which in severe cases may include pneumonia and bronchopneumonia. CPI    is a common viral upper respiratory disease. Uncomplicated CPI may be mild or    subclinical, with signs becoming more severe if concurrent infection with other    respiratory pathogens exists. CPV infection results in enteric disease characterized    by sudden onset of vomiting and diarrhea, often hemorrhagic. Leukopenia commonly    accompanies clinical signs. Susceptible dogs of any age can be affected, but    mortality is greatest in puppies. In puppies 4-12 weeks of age CPV may occasionally    cause myocarditis that can result in acute heart failure after a brief and inconspicuous    illness. Following infection many dogs are refractory to the disease for a year    or more. Similarly, seropositive bitches may transfer to their puppies CPV antibodies    which can interfere with active immunization of the puppies through 16 weeks    of age. Leptospirosis occurs in dogs of all ages, with a wide range of clinical    signs and chronic nephritis generally following acute infection. Infection with    L. canicola and L. icterohaemorrhagiae cannot be differentiated clinically.   Trial Data: Safety and Efficacy: Laboratory evaluation demonstrated    that VANGUARD&#194;&#174; Plus 5/L immunized dogs against CD, ICH, CAV-2 respiratory    disease, CPI, CPV, and leptospirosis caused by L. canicola and L. icterohaemorrhagiae,    and that no immunologic interference existed among the vaccine fractions. Extensive    field safety trials conducted by Pfizer Animal Health showed it to be safe and    reaction-free in dogs as young as 6 weeks of age under normal usage conditions.   It has been demonstrated that CAV-2 vaccine cross-protects against ICH caused    by CAV-1. The CAV-2 fraction in Vanguard&#194;&#174; vaccines is used as a replacement    for CAV-1 because it has significant advantages. Some CAV-1 vaccines may produce    undesirable reactions, including persistent kidney infections, uveitis, and    corneal opacity ("blue eye"), which have not been reported after vaccination    with CAV-2.2 In addition, the CAV-2 strain used in Vanguard&#194;&#174; vaccines has    been specially selected for freedom from oncogenic properties characteristic    of adenoviruses.  Studies conducted at Pfizer demonstrated that CAV-2 not only protects against    ICH, but against CAV-2 respiratory disease as well.3 Although conventional CAV-1    (ICH) vaccines cross-protect against CAV-2, they may not prevent subclinical    infection and spread of the CAV-2 agent. Canine adenovirus type 2 challenge    virus was not recovered from CAV-2-vaccinated dogs in tests conducted at Pfizer

## Images

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*Product available on Desertcart Uruguay*
*Store origin: UY*
*Last updated: 2026-02-21*