--- product_id: 15078466 title: "Advantage II Large Dog" brand: "advantage" price: "$U4987" currency: UYU in_stock: true reviews_count: 8 category: "Advantage" url: https://www.desertcart.uy/products/15078466-advantage-ii-large-dog store_origin: UY region: Uruguay --- # Waterproof after 24 hours Kills fleas in 12 hours 30-day continuous protection Advantage II Large Dog **Brand:** advantage **Price:** $U4987 **Availability:** ✅ In Stock ## Summary > 🐾 Stay ahead of fleas—because your dog deserves the best defense! ## Quick Answers - **What is this?** Advantage II Large Dog by advantage - **How much does it cost?** $U4987 with free shipping - **Is it available?** Yes, in stock and ready to ship - **Where can I buy it?** [www.desertcart.uy](https://www.desertcart.uy/products/15078466-advantage-ii-large-dog) ## Best For - advantage enthusiasts ## Why This Product - Trusted advantage brand quality - Free international shipping included - Worldwide delivery with tracking - 15-day hassle-free returns ## Key Features - • **Month-Long Defense:** Provides uninterrupted flea and lice protection for 30 days - • **Waterproof & Durable:** Keeps working even after your dog’s outdoor adventures - • **Effortless Application:** Topical, no prescription needed, and fragrance-free for easy use - • **Rapid Flea Elimination:** Starts killing fleas within 12 hours for fast relief - • **Vet-Recommended Formula:** Trusted by professionals for safe, effective flea control ## Overview Advantage II Large Dog Flea Treatment is a vet-recommended, topical solution designed for dogs weighing 21-55 lbs. It kills adult fleas, larvae, and eggs within 12 hours and provides 30 days of continuous protection. The fragrance-free, waterproof formula is easy to apply without a prescription, ensuring your dog stays flea-free and comfortable all month long. ## Description Product Description Advantage II Large Dog is the vet-recommended prevention and treatment of flea and lice infestations in dogs. Advantage II Large Dog flea treatment and prevention kills adult fleas, flea larvae and flea eggs to deliver total flea protection to your dog or puppy. In fact, within 12 hours of application, Advantage II Large Dog topical treatment gets straight to work killing fleas through contact, so they don’t have to bite your dog to die.This 30-day treatment effectively breaks the flea life cycle, controlling existing flea and lice infestations and preventing further infestations all month long. Fleas not only cause discomfort; they can also pose other health risks. Monthly use of Advantage II Large Dog is important to protect your dog against fleas that may cause transmission of tapeworms in dogs, Flea Allergy Dermatitis and flea bite anemia.That’s why Advantage II topical, spot-on formula makes application simple - going on in seconds. It's easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that Advantage II is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects. Advantage II Large Dog flea and lice protection is effective on both indoor and outdoor dogs. Your dog should be at least 7 weeks old and weigh 21 to 55 lbs. to use Advantage II Large Dog.For the ultimate convenience in care, Advantage II Large Dog is available over the counter – no prescription needed. And, you can stock up with a subscription for regular doorstep deliveries so you never miss a monthly treatment. Once Advantage II Large Dog is applied, your dog is ready to get right back to exploring his favorite places – from the backyard to the dog park.Advantage II Large Dog is a trademark of Elanco or its affiliates. Brand Story By Advantage Review: A Helpful Tool In Our Flea Control Regimen! - We have double coated, long haired, very furry large Northern Breed Mixed Dogs. Unfortunately, fleas are a year round problem here in the San Francisco Bay Area where we live ... Ugh! Advantage II Topical Flea Treatment & Prevention is an effective tool in our flea control regimen. - Easy to apply the topical drops on your dog's skin along the backbone. - Our dogs have never had any skin irritation or other negative reactions with this product. - The 6 pack is a terrific value. I highly recommend this product. Review: It's effective without being too potent - I've been using this for years. It works pretty good. It's becoming less and less effective as the fleas evolve to it. But right now it's still pretty effective. ## Features - Vet recommended flea treatment and prevention for dogs at weighing 21 to 55 lbs., at least 7 weeks of age - Kills adult fleas, flea larvae and flea eggs for total flea prevention and treatment - Same-day effectiveness, kills fleas within 12 hours of application and keeps working for 30 days - Easy-to-apply topical treatment, no prescription needed - Fragrance-free formula, waterproof after 24 hours ## Technical Specifications | Specification | Value | |---------------|-------| | ASIN | B004QRFJA4 | | Active Ingredients | Imidacloprid, Pyriproxyfen | | Age Range Description | 7 weeks and older | | Allergen Information | Allergen-Free | | Best Sellers Rank | #2,089 in Pet Supplies ( See Top 100 in Pet Supplies ) #18 in Dog Flea Drops | | Brand | Advantage | | Brand Name | Advantage | | Customer Reviews | 4.5 out of 5 stars 19,136 Reviews | | Dog Breed Size | Large | | Global Trade Identification Number | 00724089202833 | | Item Form | Topical | | Item Type Name | Bayer Advantage II Flea and Lice Treatment for Large Dogs, 21-55 lb, 4 doses (Packaging may vary) | | Item Volume | 10 Milliliters | | Item Weight | 17.96 g | | Manufacturer | Elanco US Inc | | Manufacturer Part Number | 86336707 | | Model Number | 86336707 | | Scent | Unscented | | Scent Name | Unscented | | Target Species | Dog | | UPC | 724089202833 | | Unit Count | 4 Count | | Volume | 10 Milliliters | ## Product Details - **Active Ingredients:** Imidacloprid, Pyriproxyfen - **Age Range (Description):** 7 weeks and older - **Allergen Information:** Allergen-Free - **Brand:** Advantage - **Dog Breed Size:** Large - **Item Form:** Topical - **Item Volume:** 10 Milliliters - **Item Weight:** 0.04 Pounds - **Scent:** Unscented - **UPC:** 724089202833 ## Images ![Advantage II Large Dog - Image 1](https://m.media-amazon.com/images/I/71cacwZn0PL.jpg) ## Available Options This product comes in different **Size, Style** options. ## Questions & Answers **Q: Is there a warning to keep the dog away from cats for 24 hours after treatment with Advantage, as is found on Frontline?** A: Yes, there is a seperate and specific warning about not using it on cats and keeping dogs away from cats for 24 hrs. Highlited in yellow. **Q: Is it ok to put advantix and advantage ii simultaneously on a larger dog? advantix for l and advantage ii for sm. that amount needed for bigger dog.** A: Each box will have a different expiration date on it. We had a box for at least a year, it still worked on the dog. **Q: What are ingredients?** A: Strange that they leave this part out of the description as it is rather important. I have used this product on several dogs for years and purchased here and the online pet pharmacy out of Canada (wife ordered and I forget the name) but never had a problem but just like humans, some dogs have different reactions than others to certain products/chemicals, so do be careful to follow directions and monitor a bit to make sure your pet is taking it as expected and not having any reactions. Since they don't list it, I would email them seller directly, and/or look on the manufacturer website for more info. **Q: what is the difference between Advantage 11 and Advantage?** A: Advantage II Is a better flea control and does not wash off as does Advantage. Advantage II is what you want! ## Customer Reviews ### ⭐⭐⭐⭐⭐ A Helpful Tool In Our Flea Control Regimen! *by M***S on January 3, 2026* We have double coated, long haired, very furry large Northern Breed Mixed Dogs. Unfortunately, fleas are a year round problem here in the San Francisco Bay Area where we live ... Ugh! Advantage II Topical Flea Treatment & Prevention is an effective tool in our flea control regimen. - Easy to apply the topical drops on your dog's skin along the backbone. - Our dogs have never had any skin irritation or other negative reactions with this product. - The 6 pack is a terrific value. I highly recommend this product. ### ⭐⭐⭐⭐⭐ It's effective without being too potent *by B***Y on March 8, 2026* I've been using this for years. It works pretty good. It's becoming less and less effective as the fleas evolve to it. But right now it's still pretty effective. ### ⭐⭐⭐⭐⭐ Best price around beat all local vendors *by K***R on March 15, 2026* There was no issues with hair loss, scratching caused by the product. Best price compared to local stores ## Frequently Bought Together - Advantage II Large Dog Vet-Recommended Flea Treatment & Prevention | Dogs 21-55 lbs. | 4-Month Supply - Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 6-Month Supply - Advantage II Medium Dog Vet-Recommended Flea Treatment & Prevention | Dogs 11-20 lbs. | 4-Month Supply --- ## Why Shop on Desertcart? - 🛒 **Trusted by 1.3+ Million Shoppers** — Serving international shoppers since 2016 - 🌍 **Shop Globally** — Access 737+ million products across 21 categories - 💰 **No Hidden Fees** — All customs, duties, and taxes included in the price - 🔄 **15-Day Free Returns** — Hassle-free returns (30 days for PRO members) - 🔒 **Secure Payments** — Trusted payment options with buyer protection - ⭐ **TrustPilot Rated 4.5/5** — Based on 8,000+ happy customer reviews **Shop now:** [https://www.desertcart.uy/products/15078466-advantage-ii-large-dog](https://www.desertcart.uy/products/15078466-advantage-ii-large-dog) --- *Product available on Desertcart Uruguay* *Store origin: UY* *Last updated: 2026-05-03*