---
product_id: 4114433
title: "FRONTLINE Plus Flea and Tick Treatment for X-Large Dogs Up to 89 to 132 lbs. 3 Treatments"
brand: "frontline"
price: "$U4051"
currency: UYU
in_stock: true
reviews_count: 9
category: "Frontline"
url: https://www.desertcart.uy/products/4114433-frontline-plus-flea-and-tick-treatment-for-x-large-dogs
store_origin: UY
region: Uruguay
---

# 30-day continuous protection For extra-large dogs 89-132 lbs Waterproof formula FRONTLINE Plus Flea and Tick Treatment for X-Large Dogs Up to 89 to 132 lbs. 3 Treatments

**Brand:** frontline
**Price:** $U4051
**Availability:** ✅ In Stock

## Summary

> 🐾 Stay ahead of pests with FRONTLINE Plus — because your big dog deserves big protection!

## Quick Answers

- **What is this?** FRONTLINE Plus Flea and Tick Treatment for X-Large Dogs Up to 89 to 132 lbs. 3 Treatments by frontline
- **How much does it cost?** $U4051 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.uy](https://www.desertcart.uy/products/4114433-frontline-plus-flea-and-tick-treatment-for-x-large-dogs)

## Best For

- frontline enthusiasts

## Why This Product

- Trusted frontline brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Easy Monthly Application:** Single-point topical treatment designed for hassle-free use on large breeds.
- • **Trusted for Over 20 Years:** Veteran pet owners swear by FRONTLINE’s proven, reliable formula.
- • **Kills Fleas at Every Stage:** Targets adult fleas, eggs, larvae, and chewing lice to break the infestation cycle.
- • **Month-Long Flea & Tick Defense:** One fast-acting dose shields your dog for a full 30 days, so you never miss a beat.
- • **Waterproof & Active Even When Wet:** Unique sebaceous gland delivery keeps protection flowing, rain or shine.

## Overview

FRONTLINE Plus Flea and Tick Treatment for X-Large Dogs (89-132 lbs) offers a waterproof, fast-acting topical solution that kills fleas, flea eggs, larvae, chewing lice, and ticks for 30 days. Trusted by pet owners for over two decades, it uses a dual-action formula with fipronil and (S)-methoprene to break the flea life cycle. Easy to apply monthly, it continuously replenishes through sebaceous glands, ensuring lasting protection even if your dog gets wet.

## Description

Product Description Keep your dog protected with the number 1 name in flea & tick protection (1), FRONTLINE. FRONTLINE Plus for Dogs is a fast-acting, long-lasting waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease. Break the flea life cycle — FRONTLINE Plus for Dogs is specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control. Trusted by pet owners for over 20 years (2) — FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply. Applied to a single point on your pet, the flea and tick control treatment covers your dog's entire body and deposits in the sebaceous glands. These glands act as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet. Just one dose of FRONTLINE Plus each month protects against fleas & ticks for a full 30 days. FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products. Appropriately treat all pets in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations. Subscribe and save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus. Be sure to visit our brand store and follow us to stay up to date on new FRONTLINE products, features, tips and more. References: (1) BI Marketing Excellence Survey performed by Kynetec, November 2023. (2) 20 years of trust in killing fleas and ticks demonstrated by various studies in the past 20 years including a 2002 Pet Owner Brand Awareness and Attitude Tracking Study performed by Bruno and Ridgway Research Associates and the 2023 BrandSpark© American Trust Study where FRONTLINE Brand Products were voted most trusted for brand for flea & tick prevention. Brand Story By Frontline Plus

Review: This stuff still works great - I bought this because I remember, this was the first thing that came out to kill fleas & ticks! I haven't seen any in years! I'm glad I found it on desertcart! Because I can't afford the other stuff & too! The other stuff I don't really trust it much! This is well worth the money, & has worked great on my 116 pound German shepherd, yup she could lose a few pounds. But she's not scratched for fleas.. she does have dry skin. There was no smell & always fell safe applying the tube opening it away from me & applying it between the shoulder's! So thankful they still make Frontline & it works! Am definitely going to be buying more!
Review: Still works in my part of the state - Easy to apply if you can make a part in your dog's hair. I always get it on my hands and wash it off as soon as I am done with the dogs. Never a problem on my skin due to this timeliness I guess. Kills the ticks who settle down to bite and still works on fleas for me. Ten miles down the road, however, it does not work anymore. Life finds away...

## Features

- Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
- Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
- Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
- FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
- Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations
- Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B0002J1FP8 |
| ASIN  | B0002J1FP8 |
| Age Range Description | All Life Stages |
| Best Sellers Rank | #2,007 in Pet Supplies ( See Top 100 in Pet Supplies ) #12 in Dog Flea Drops |
| Brand Name | Frontline |
| Breed Recommendation | Large Breeds |
| Color | Red Box |
| Country of Origin | France |
| Customer Reviews | 4.4 4.4 out of 5 stars (15,144) |
| Date First Available | May 30, 2004 |
| Date First Available  | May 30, 2004 |
| Department | Flea & Tick |
| Department  | Flea & Tick |
| Directions | Directions for Use Step 1. To REMOVE Applicator: 1. Use scissors to separate one blister; 2. Use scissors to cut along dotted line; 3. Peel down foil to remove the applicator. Step 2. OPEN Applicator. Hold upright with foil side toward you and snap applicator tip. Step 3. APPLY FRONTLINE Plus. Part the dog’s hair between the shoulder blades. Place the applicator tip just above the skin and squeeze… |
| Included Components | Package includes 3 applicators |
| Is Discontinued By Manufacturer  | No |
| Item Dimensions LxWxH | 5.75 x 0.75 x 4.5 inches |
| Item Package Dimensions L x W x H | 5.87 x 4.37 x 0.75 inches |
| Item Weight | 1.6 Ounces |
| Item model number | 72220 |
| Item model number  | 72220 |
| Manufacturer | Boehringer Ingelheim Animal Health |
| Manufacturer  | Boehringer Ingelheim Animal Health |
| Manufacturer recommended age  | 1 month and up |
| Model Name | FRONTLINE Plus Extra Large Dog |
| Number of Items | 3 |
| Product Dimensions  | 5.75 x 0.75 x 4.5 inches; 1.6 ounces |
| Size | 3 Count |
| Specific Uses for Product | Parasites |
| Style | 3 Count |
| Target Audience Keyword | dogs |
| Warranty Description | If you are not satisfied with FRONTLINE Plus for any reason, please contact the Boehringer-Ingelheim Animal Health Customer Care Team at: 1-800-660-1842 |

## Product Details

- **Active Ingredients:** fipronil and (S)-methoprene
- **Age Range (Description):** All Life Stages
- **Allergen Information:** Abalone Free
- **Brand:** Frontline
- **Dog Breed Size:** Large
- **Global Trade Identification Number:** 00350604287308
- **Item Form:** Liquid
- **Item Volume:** 302.4 Milliliters
- **Item Weight:** 1.6 Ounces
- **Scent:** Unscented

## Images

![FRONTLINE Plus Flea and Tick Treatment for X-Large Dogs Up to 89 to 132 lbs. 3 Treatments - Image 1](https://m.media-amazon.com/images/I/71FiB6zP-3L.jpg)

## Available Options

This product comes in different **Size** options.

## Questions & Answers

**Q: Does this product have an EPA number on the box?**
A: Yes it does. It's 100% USA EPA Registered and legal for sale in the USA.

**Q: What are the active ingredients?**
A: Zoom in on box, switched from advantage appears to work well.

**Q: Does the product kill ticks throughout the dogs body and not just near the application site?**
A: Throughout the body.  Our dogs have not had ticks for years, although you do need to continue to check them.

**Q: Will this work for a dog that is 210 lbs**
A: I have a 200 lb Great Dane and works for him…the best is the chew that lasts 3 months…have to get from vet and very expensive

## Customer Reviews

### ⭐⭐⭐⭐⭐ This stuff still works great
*by T***E on December 29, 2025*

I bought this because I remember, this was the first thing that came out to kill fleas & ticks! I haven't seen any in years! I'm glad I found it on Amazon! Because I can't afford the other stuff & too! The other stuff I don't really trust it much! This is well worth the money, & has worked great on my 116 pound German shepherd, yup she could lose a few pounds. But she's not scratched for fleas.. she does have dry skin. There was no smell & always fell safe applying the tube opening it away from me & applying it between the shoulder's! So thankful they still make Frontline & it works! Am definitely going to be buying more!

### ⭐⭐⭐⭐⭐ Still works in my part of the state
*by S***H on September 23, 2024*

Easy to apply if you can make a part in your dog's hair. I always get it on my hands and wash it off as soon as I am done with the dogs. Never a problem on my skin due to this timeliness I guess. Kills the ticks who settle down to bite and still works on fleas for me. Ten miles down the road, however, it does not work anymore. Life finds away...

### ⭐⭐⭐⭐⭐ Medicine
*by S***. on February 14, 2026*

It help to keep the ticks and flees away from the dogs

## Frequently Bought Together

- Frontline Plus Flea and Tick Treatment for X-Large Dogs Up to 89 to 132 lbs. 3 Treatments
- Frontline Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments
- Frontline Plus Flea and Tick Treatment for Small Dogs Upto 5 to 22 lbs. 3 Treatments

---

## Why Shop on Desertcart?

- 🛒 **Trusted by 1.3+ Million Shoppers** — Serving international shoppers since 2016
- 🌍 **Shop Globally** — Access 737+ million products across 21 categories
- 💰 **No Hidden Fees** — All customs, duties, and taxes included in the price
- 🔄 **15-Day Free Returns** — Hassle-free returns (30 days for PRO members)
- 🔒 **Secure Payments** — Trusted payment options with buyer protection
- ⭐ **TrustPilot Rated 4.5/5** — Based on 8,000+ happy customer reviews

**Shop now:** [https://www.desertcart.uy/products/4114433-frontline-plus-flea-and-tick-treatment-for-x-large-dogs](https://www.desertcart.uy/products/4114433-frontline-plus-flea-and-tick-treatment-for-x-large-dogs)

---

*Product available on Desertcart Uruguay*
*Store origin: UY*
*Last updated: 2026-03-15*