

🐾 Stay ahead of pests with FRONTLINE Plus — because your dog deserves the best!
FRONTLINE Plus Flea and Tick Treatment offers fast, waterproof, and long-lasting protection for large dogs (45-88 lbs). Using proven active ingredients fipronil and (S)-methoprene, it kills adult fleas, ticks, lice, mites, and flea eggs/larvae. Trusted for over 20 years, this easy monthly topical treatment ensures your dog stays pest-free even after water exposure, making it the go-to choice for proactive pet parents.


















| Active Ingredients | fipronil and (S)-methoprene |
| Brand | Frontline |
| Customer Reviews | 4.4 out of 5 stars 49,388 Reviews |
| Item Form | Liquid |
| Item Volume | 12 Milliliters |
| Item Weight | 2.89 Ounces |
| Scent | Unscented |
V**S
Keeps the fleas away
Frontline works great no fleas on my dog. I have been using this brand for years
J**I
Works perfectly!
⭐️⭐️⭐️⭐️⭐️ Works perfectly! FRONTLINE Plus worked perfectly for my dog. It keeps him safe from fleas and ticks, even though he loves running around the yard. Very reliable and effective!
Y**S
I like
It's definitely something I would buy again. It comes with three applications, and you can use it once a month, so it provides coverage for 3 months.
K**E
May have worked
I think may have worked for my dogs . The only thing I have a complaint about is that the treatment itself is not enough I have two dogs and I had to use all three of these on them from between their shoulder blades to their tail. I’ve haven’t seen any fleas on them since using this but I’m not sure .
A**R
Tried and true product for Lyme disease prevention
Tried and true product. As a general rule, I do not like having to put chemicals on my dogs. But we live in an area where the ticks are atrocious and some years are worse than others. So I struggle with putting chemicals on the dogs versus having them contract Lyme disease so I do use this product when I feel that I have to. I have never had a dog have a reaction to Frontline, and we have had dogs for 25 years. It works immediately. I wish they would come out with a product like this for people. I had a tick crawling down my neck the other day and it really freaked me out. Good price and fast shipping.
K**A
Thank God!
I have two Malteses and they had SERIOUS fleas. One of my poor babies was simply crawling and could not go long without scratching. I tried the Little City Dogs products last month (both the Capsar knockoff and the Program knockoff) and neither did a thing. I didn't want to use another product immediately, so I waited a long month to buy Frontline Plus. I have used Frontline Plus successfully in the past, but the price gave me pause this time around. I had also heard that the product was becoming less effective. That does not seem to be the case for the fleas in my neck of the woods (and by neck of the woods I mean Philadelphia). 24 hours after applying Frontline Plus one of my dogs was flea free and the other had slow-moving fleas. It looked like a flea death march. 48 hours after applying the product both are free of live fleas and look much more comfortable. One still has flea dust which I will comb out later today. I did purchase the product for large dogs and distributed an appropriately sized dose to each of my small dogs. This was a cost saving measure that I am NOT recommending to others as I am not a vet. So, this batch would last me three months for both dogs. I discard the extra in the vial. Important Notes: (1) Do not wash your dog for at least a few days prior to treatment. The sweat in the hair and on the skin helps the product to adhere. (2) Do not wash your dogs for at least a few days after treatment for this same reason. (3) Read the box carefully, and return it if you see any red flags (i.e. product name on vial does not match box) Also, in response to the "Buyer Beware" posted on 10/15/12. My product has none of the issues that this reviewer mentioned. 1. I did receive calendar stickers with the product. 2. The back of the vial was properly labeled "Frontline Plus" 3. My vials were sealed appropriately (and were quite difficult to open). I didn't check my lot number, but all in all this product seems fully legitimate to me.
S**L
Didn't prevent fleas but Seresto collar did
The Frontline Plus flea and tick control for 45 to 88 pound dogs was worse than a disappointment. My dog is 50 pounds--well within the dosage range and become infested with fleas during the second month/dosage of usage. I'm not sure if the preventative actually worked the first month or if I just didn't notice the fleas until the fleas had multiplied enough for me to easily see them. I also don't know if I received the same quailty Frontline product through Amazon as a store/vet purchase. I have no reason to think that this was an imitation product other than some suspicions by other reviewers. Regardless, I had to use a flea dip and flea bomb my house. Once an infestation occurs, getting rid of the fleas is quite an aggravation. I'm trying Advantage II from PetSmart now to see if that will work. Hopefully, something will. June 24 2013, Advantage II didn't work either. I've had acceptable success from Certifect which I buy from my vet. I've used Certifect for over a year now. These flea and tick drops are made by Frontline but are only sold by prescription or thru a vetinarian. It works great for ticks. I've not had any problems with ticks from the first dosage. For a few days, though, after the dosage, he is a bit lethargic. However, my dog will still pick up fleas. The drops do kill the fleas but don't repel them quickly enough. Many people are having trouble with fleas because of the sucession of mild winters. The flea population isn't culled enough. During the summer months, the fleas just seem to overwhelm the medication and flea dips or additional organic sprays are necessary. I've been told that a new flea and tick pill may now be available. I know the flea pill works but I hadn't used it because I needed something for ticks. If this rumor is true, I'll definately give the pill a try. December 30, 2014. I finally found something that actually works for controlling fleas and ticks for my now 70 pound Labrador/mix. (He was a stray that my family adopted--short hair.) My vet introduced me to a new product (at the time) made by Bayer. It's a flea collar called Seresto that is sold on Amazon. I couldn't believe that a flea collar would really work. But, after having to hire Orkin to get the fleas out of my home, I was willing to try it. It's the best product that I have used for fleas and ticks. It's easy to use. I just put the collar on my dog. In few days all fleas were gone. The only ticks I ever find on my dog are the ones that he picks up during a walk or bush adventure. They are easily brushed off (when I notice them) and never attach. The collar lasts as long as advertised--8 months or in our case 5 months since he likes to swim. Unlike the drops, he is never lethargic afterwards. I have used several of these Seresto collars now and can't recommend them enough. They are sold on Amazon, by veterinarians, and I've seen them at Pet Smart as well.
C**D
Kills ticks...though a little late
My 65 pound lab mix loves to go for hikes in the woods every week, but in central PA our wooded areas have a massive tick problem. I bought the Frontline Plus Flea and Tick Control liquid treatment because it has been recommended to me before, including by my vet. The product packaging also claims it will “kill 100% of adult fleas and 100% of all ticks within 48 hours.” It also claims to be waterproof for 30 days, and to “kill all eggs left on the dog’s coat.” After applying the capsule to our dog’s back, we took her on the trails the following week and after checking her right after, we didn’t find any ticks. However, two days later she did manage to scratch a tick off of her and fling it onto the coffee table! The tick was full, like a berry, and utterly disgusting, but the product worked. The tick was dead, as promised. It should be made known that although the tick was dead, and so it was unable (supposedly) to lay eggs on our dog (typically a tick will lay 50 eggs a day on your dog, I read, while Frontline claims to kill ticks within hours before this can happen), ticks can obviously still bite your dog with this product on them, which can still effectively expose your dog to Lyme disease. This bothers me, since the idea behind applying it in the first place was that we don’t want ticks biting her at all so she can avoid Lymes altogether. The product lost some points with me here. The company, Merial, which manufactures Frontline, is a global company responsible for producing vaccines and medications for farm animals as well as pets. They seem to have a reputable track record, with 5 manufacturing sites in the United States as well as other countries. According to my research, and what is posted on the Merial website, Frontline Plus uses two major chemicals to achieve results of killing fleas and ticks. Both of the chemicals, S-Methoprene and Fipronil are harmless to mammals. According to one report I read online, however, about 5% of the fipronil does get absorbed into the dog’s bloodstream, which can metabolate into a different compound which can be up to 20% more harmful to your dog than it is to the insects. The website where I found that information, Dogs Naturally Magazine, seems a bit biased, though, in its interests. Further research showed that around 80 percent of the contents of Frontline Plus are not chemicals that fight pests, they are ethanol, glycol ether, and otherwise “inactive” ingredients. Since these “other” ingredients are inert, Merial doesn’t have to disclose much about them. I didn’t notice any weird side effects with my dog after using Frontline, but part of me still wonders if it’s the safest thing for her, since the company didn’t list the other ingredients in the product. It’s a bit off-putting. After doing some research, it does appear vets have conflicting ideas about Frontline use. Some believe it is linked to major illness that can potentially be linked to a dog’s death, while others claim there is nothing to be concerned about. Many respond to the rumors that Frontline is not healthy for dogs by acknowledging that many people apply the product incorrectly to their dog, resulting in pets having a reaction. Also, you’re not supposed to put the product onto raw skin areas or open wounds on your pet, or feed it to your pet, as the box also warns. The consensus among most veterinarians, and myself, is that while there are more natural ways of protecting your dog against ticks (some people suggest neem oil as a good alternative - whatever that is!), using more natural methods may result in your dog getting more ticks, which may then lead to higher risks of contracting tick-borne illness. In a place where the tick problem is so rampant, like where we live, I’d rather not take my chances. Not using a chemical prevention method is a tradeoff many pet owners feel is not worth the risk. Overall, the product did what it said it was going to do, and for that it gets 5 stars. But because I don’t have a clear idea of what “other ingredients” are (the company does not disclose them on the packaging), and because the product didn’t kill a tick before it bit my dog, I give it an average of 3 stars. My expectations were higher than what the product delivered. Although, this was my pet’s first time using Frontline, so I’m wondering if more consistent treatment will lead to better results.
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